What is tesamorelin?
Tesamorelin is approved to reduce excess abdominal fat in adults with HIV who have lipodystrophy. Its effect on cardiovascular health and long-term outcomes has not been established. It is not indicated for weight loss management.
How it works
Tesamorelin is a synthetic growth hormone–releasing factor analog. It stimulates the pituitary gland to release growth hormone, which can reduce visceral abdominal fat in indicated patients.
Potential benefits for indicated patients
- In clinical trials, reduction of visceral abdominal fat in adults with HIV-associated lipodystrophy
Individual results vary. Outcomes are not guaranteed.
Who may qualify
- Adults living with HIV who have excess abdominal fat from lipodystrophy
- Review of cancer history, pituitary conditions, and glucose control
- Medical evaluation required
Important safety information
Contraindications
- Disruption of the hypothalamic-pituitary axis (e.g., pituitary surgery, tumor, or radiation)
- Active malignancy
- Pregnancy
- Hypersensitivity to tesamorelin or mannitol
Warnings & precautions
- Elevated IGF-1 levels
- Fluid retention, joint pain, carpal tunnel symptoms
- Glucose intolerance or diabetes
- Hypersensitivity reactions, injection-site reactions
Common side effects
- Joint and muscle pain
- Swelling of the extremities
- Injection-site redness or itching
Drug interactions
- Medications metabolized by CYP450 enzymes
- Glucocorticoid replacement may need adjustment
Pregnancy
Contraindicated in pregnancy. Breastfeeding is not recommended for people with HIV.
Monitoring
IGF-1 levels, blood glucose, and periodic reassessment of benefit.
This summary is not complete. Review the full prescribing information and discuss risks with your clinician.
Treatment process
01
Evaluation
Secure assessment and clinician review.
02
Prescribing
Issued only if clinically appropriate.
03
Fulfillment
Through a licensed pharmacy, subject to availability.
04
Follow-up
Ongoing monitoring and support.
Frequently asked questions
Is tesamorelin a weight-loss medication?
No. It is FDA-approved only for reducing excess abdominal fat in adults with HIV-associated lipodystrophy.
Can I request it for anti-aging?
Evolo Health does not prescribe tesamorelin for anti-aging, bodybuilding, or longevity purposes.
