Overview
Bremelanotide is an as-needed injection used before anticipated sexual activity in premenopausal women with acquired, generalized HSDD. It is not indicated for postmenopausal women, men, or to enhance sexual performance.
How it works
Bremelanotide activates melanocortin receptors in the brain. The exact way it improves sexual desire is not fully understood.
Potential benefits
- In clinical trials, some eligible women experienced increased desire and reduced distress related to low desire
Individual results vary. Outcomes are not guaranteed.
Who may qualify
- Premenopausal women with acquired, generalized low sexual desire causing distress
- Not explained by another medical or psychiatric condition, medication, or relationship issue
- Clinician evaluation required
Important safety information
Contraindications
- Uncontrolled high blood pressure or known cardiovascular disease
Warnings & precautions
- Transient increase in blood pressure and decrease in heart rate after each dose
- Focal hyperpigmentation (darkening of skin/gums), especially with frequent use
- Nausea, which may be severe
Common side effects
- Nausea, flushing
- Injection-site reactions, headache
- Vomiting
Drug interactions
- May slow absorption of oral medications, including naltrexone (contraindicated combination with oral naltrexone)
Pregnancy
Discontinue if pregnant. Use effective contraception.
Monitoring
Blood pressure assessment; discontinue after 8 weeks if no improvement.
This summary is not complete. Review the full prescribing information and discuss risks with your clinician.
Treatment process
01
Evaluation
Secure assessment and clinician review.
02
Prescribing
Issued only if clinically appropriate.
03
Fulfillment
Through a licensed pharmacy, subject to availability.
04
Follow-up
Ongoing monitoring and support.
Frequently asked questions
Can men use PT-141?
Bremelanotide is not FDA-approved for use in men. Evolo Health does not market it for men or for general sexual enhancement.
How often can it be used?
No more than one dose per 24 hours and no more than eight doses per month, per labeling.
Is a compounded version the same as the FDA-approved product?
No. Compounded medications are not FDA-approved, have not been reviewed by the FDA for safety, effectiveness, or quality, and are not equivalent to approved products. They may only be prescribed when legally permitted and clinically appropriate.
